The Perrio siblings struggle with different stages of weight loss.
Lee and Rena make another attempt at weight loss to save their lives.
At over 600 pounds, Janine is immobile and pursues weight-loss surgery.
Alicia is afraid she'll die before she can marry or see her nieces grow up.
Liz attempts to reclaim her health and mobility with weight loss surgery.
At over 600 pounds and barely able to bathe herself, Karina makes a change.
After losing a leg and battling obesity, LB pursues weight loss surgery.
Lisa attempts to save her life with weight-loss surgery.
At almost 900 pounds, Robert desperately attempts to lose weight.
At over 500 pounds, Tamy hopes to restart her life.
Brothers David and Benji face weight-loss surgery together.
At over 600 pounds, former plus-size model Renee works to regain control.
At over 600 pounds, Sarah is fighting for her life at just 24 years old.
At almost 700 pounds, Schenee attempts to lose weight and start a family.
Jennifer and her daughter Marissa attempt weight-loss surgery together.
The three Perrio siblings have one last chance to lose weight.
